Evaluation of Narrative Evidence on the Impact of the Gut Microbiome on the Progression of Alzheimer’s disease

Abstract

Alzheimer’s disease (AD) is a progressive and debilitating neurodegenerative disorder characterized primarily by cognitive decline and memory impairment. A major pathological hallmark of AD is the accumulation of amyloid-beta (Aβ) plaques, which is associated with impaired neuronal growth, disruption of synaptic connectivity, and progressive neuronal dysfunction. Synaptic dysfunction is considered one of the key mechanisms underlying the cognitive deficits observed in patients with AD. Excessive accumulation of Aβ can adversely affect synaptic function and contribute to the progression of neurodegeneration.

The gut microbiota plays an important role in maintaining communication between the gastrointestinal tract and the nervous system and in regulating immune and inflammatory processes. Alterations in the composition and function of the gut microbiota, commonly referred to as gut dysbiosis, may promote systemic and neuroinflammation, influence Aβ metabolism and accumulation, and thereby contribute to the development and progression of Alzheimer’s disease.

As a result, Alzheimer's disease is the most common dementia in the aging world population; Various factors cause this disease, but disrupting the intestinal microbiota causes disruption in neurons and causes Alzheimer's.